New Step by Step Map For cees dekker
New Step by Step Map For cees dekker
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‘Of course, that's about correct. I seek for a physical knowledge of Organic systems within a base-up way. I think you may distinguish a few strains of analysis in my team for the time being. The primary fears chromosome structure: How would you obtain a metre-prolonged DNA polymer folded and organised in this kind of microscopic mobile? We've designed visualisation procedures that allow us to study how, one example is, SMC proteins loop DNA (online video on Youtube) in order to Develop up chromosomes.
Our team scientific tests bacterial mobile division and is also aiming to constitute a ‘base up biology’ in artificial cells which will autonomously divide. Our key fascination lies in cell division, chromatin composition, and spatial Regulate.
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Deposition and atomic pressure microscopy of particular person phthalocyanine polymers in between nanofabricated electrodes
De sterke polarisatie in de discussie rond schepping/evolutie en meer algemeen rond geloof/wetenschap lijkt helaas geen eind te kennen. Toch is er wel degelijk een heilzame middenweg, maar deze krijgt around het algemeen weinig aandacht. Dit boek kan hier wellicht verandering in brengen. Wie de geschiedenis van de relatie tussen geloof en wetenschap in duikt, komt tot verrassende inzichten. De moderne mens leeft fulfilled veel stereotypen die historisch niet verantwoord blijken te zijn. Afgezaagde typeringen als ‘Vroeger dachten we dat de
Cornelis (Cees) Dekker (Haren, 7 april 1959) is een Nederlandse natuurkundige en universiteitshoogleraar verbonden aan de Technische Universiteit Delft. Van 2010 tot en satisfied 2018 was hij tevens directeur van het Kavli Institute of Nanoscience in Delft. Zijn vakgebied is de moleculaire biofysica; hierbij beweegt hij zich op het grensvlak van de natuurkunde en de biologie waarbij hij gebruikmaakt van de zogeheten nanotechnologie, de technieken om aan enkele atomen en moleculen te kunnen meten.
We use nanofabricated microfluidic constructions to pattern spatial boundaries for germs and biomimetic vesicles with reconstituted protein networks and this assess the elemental job of spatial confinement at the molecular and mobile stage. Our initiatives include things like the next:
Nanopores symbolize an elegant and flexible Instrument to measure single molecules. We study novel detection modes with strong-state nanopores as well as numerous methods to measure proteins with nanopores. Projects encompass the subsequent:
2003, demonstrated the ceesdekker.net first biosensors made outside of a carbon nanotube; solved the framework and mechanism of DNA repair proteins; and discovery of a new system for fabricating stable-condition nanopores for DNA translocation
Quite neat, but that wasn’t actually where by my interest lay. I wished to pioneer And that i experienced the feeling that was no more probable, because the most exciting essential insights had previously been uncovered. But my industry experienced developed several enjoyable new applications to measure personal molecules. I made a decision which i needed to apply this to biology, to look at it from a Bodily viewpoint.’
Screening pseudotopological and nontopological models for SMC-driven DNA loop extrusion from roadblock-traversal experiments
Many new phenomena ended up identified, and he and his investigate group established a number one position With this area of investigate. Dekker and his exploration group learned new physics of nanotubes along with explored the feasibility of molecular electronics. In 1998, they were being the initial to make a transistor depending on only one nanotube molecule.
2005, discovery of the mechanism of DNA uncoiling by topoisomerase enzymes; discovery of extensive-assortment conformational changes in Mre11/DNA fix complexes; and to start with power measurements over a DNA molecule in a nanopore
Finally, I will briefly sketch some of our Suggestions to investigate the constructing of artificial cells, exclusively our initially techniques to determine artificial mobile division.